Long-term Ibuprofen and Aspirin Use Linked to Lower Alzheimer’s Risk

By Jessica Freeborn on March 13, 2025 — Fact checked by Jill Seladi-Schulman, Ph.D.

Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin may significantly reduce the risk of developing dementia, according to a recent study. These commonly used medications, while primarily used for pain relief, have been shown to have potential benefits against serious cognitive decline.

Key Points:

• NSAIDs may reduce inflammation, playing a crucial role in dementia development.
• Study analyzed data from 11,745 participants, finding long-term NSAID use lowered dementia risk.
• Short-term or intermediate NSAID use was associated with a slight increase in dementia risk.

How Does NSAID Use Impact Dementia Risk?

The study, published in the Journal of the American Geriatrics Society, highlighted the relationship between NSAIDs and inflammation, which may be crucial in understanding dementia risk. Participants in the analysis were aged around 66 years old, with regular screenings performed to detect dementia.

Long-Term NSAID Use Linked to Lower Dementia Risk

With an average follow-up time of about 14.5 years, researchers discovered that about 81.3% of participants used NSAIDs. Notably, users of NSAIDs that do not lower beta-amyloid-42 levels appeared to have a greater reduction in all-cause dementia risk.

“The study suggests chronic inflammation could contribute significantly to neurodegeneration,” says Dr. Vernon Williams, a sports neurologist.

Study Limitations

While findings are promising, the study had limitations, including a lack of diversity among participants and reliance on observational data without random assignment. Additionally, the study could not establish a direct cause-and-effect relationship.

What Could This Mean for Clinical Practice?

This research could signal changes in how NSAIDs are utilized in clinical settings. However, no one should start taking NSAIDs without consulting healthcare professionals.

Opinion & Analysis

Overall, the evidence hinting at the protective effect of NSAIDs against dementia is compelling. Yet, further research, including controlled trials, is essential to confirm these results and better understand the implications for patients at risk of cognitive decline.

For a deeper dive into this study and its implications, check out the full article